Most supplements start with a formula and retrofit the science. We did the opposite.

The mm: approach

Multi Fuel began with you—your fatigue, brain fog, digestive discomfort, the way alcohol lingers in your gut, liver, and triggers immune systems. Then we turned to decades of scientific research to build Multi Fuel from the ground up.

Rather than targeting symptoms in isolation, we focused on synergy. When the gut, liver, and immune system are supported in concert, recovery becomes resilient. Every ingredient was chosen based on scientific validations - beyond simple standalone effects.

01 The Problem

Most people think hangovers are just about the liver—but alcohol affects far more than that. It disrupts the gut balance, your immune system, produces toxins throughout the body and sets off immune responses that leave you feeling off the next morning.

These effects aren’t isolated—they’re deeply interconnected. A compromised gut leaks toxins and blocks nutrient absorption. A strained liver struggles to clear toxic byproducts. A triggered immune system amplifies fatigue and inflammation. This cycle is what makes hangovers feel worse than just “a rough morning.”

01 Alcohol starts from the gut

Alcohol is absorbed primarily through the stomach (20%) and small intestine (80%) [1] , where it immediately begins disrupting the gut microbiome and damaging the intestinal lining. [2][3][4] This imbalance—known as dysbiosis—leads to digestive discomfort and increased intestinal permeability, or "leaky gut," allowing harmful substances to enter the bloodstream. [5] [6]

02 Liver metabolizes alcohol into toxins

Once alcohol reaches the liver, it’s broken down into acetaldehyde—a toxin more harmful than alcohol itself—and then into acetate. This process also generates reactive oxygen species (ROS), which cause oxidative stress and damage cells. [7][8]

03 Toxins build up and trigger inflammatory responses

As these toxic byproducts accumulate, they activate immune responses in the liver [9][10], leading to inflammation that manifests as nausea, headaches, fatigue, and brain fog—the core symptoms of a hangover [11][12] [13].

04 A weakened gut worsens the impact

A weakened gut lining causes toxins to flood the liver and trigger immune responses that drive inflammation, causing headaches, nausea, fatigue, and even anxiety-like symptoms. As the gut keeps leaking and the liver stays overwhelmed, a vicious cycle sets in, making it harder for your body to recover and feel normal the next day. [14][15]

02 Our Solution

Breaking the Cycle

To break the cycle of hangovers, a holistic approach targeting the gut, liver, and immune system is essential. By leveraging over 30 years of microbiome and nutritional research, strategic supplementation can enhance the body’s natural ability to detoxify and metabolize alcohol, accelerating recovery and promoting overall wellness.

01 Advanced Liver Detox & Toxin Clearance

Curcumin and dihydromyricetin (DHM) to accelerate alcohol detox and protect liver cells from oxidative stress. Curcumin, the active compound in turmeric, has been shown to reduce alcohol-induced liver injury, suppress ROS (reactive oxygen species), and boost antioxidant enzyme activity.[16][17][18] DHM, a flavonoid from Ampelopsis grossedentata, complements curcumin by enhancing the activity of alcohol-metabolizing enzymes and speeding the breakdown of acetaldehyde, alcohol’s most harmful intermediate.[19][20][21]

02 Gut Microbiome Boosting

Safe, alcohol-resilient prebiotic + probiotic complexes designed to enhance alcohol metabolism can restore microbial balance and gut integrity. Lacticaseibacillus rhamnosus and Bacillus coagulans have been shown to reduce alcohol-induced gut barrier damage and inflammation in both the gut and liver.[22][23][24]. Prebiotic fibers inulin and FOS fuel beneficial bacteria and support the production of short-chain fatty acids (SCFAs) [25][26][27][28][29], which rebalance the microbiome disrupted by alcohol [30]. Overall, this improves digestion and helps with bloating, diarrhea, and fatigue, symptoms commonly linked to gut dysfunction [31][32][33]

03 Cellular Protection Against Oxidative Stress

Alcohol increases reactive oxygen species (ROS), which damage liver cells and trigger inflammatory reactions. Citrus sinensis, which is rich in natural flavonoids like hesperidin and naringin [34], have been shown to be packed with powerful antioxidant properties that can help combat these inflammatory reactions [35][36]. Antioxidants can neutralize reactive oxygen species (ROS), toxic byproducts commonly associated with higher hangover severity [37].

04 Immune Balance

Hangover symptoms like headaches and brain fog are closely tied to inflammation [38][39]. Specially designed prebiotics + probiotics complexes can help rebalance these responses by strengthening the gut lining —reducing the leak of inflammatory molecules—and by supporting antioxidant defenses with ingredients like curcumin and citrus bioflavonoids. This helps calm inflammation and restore clarity, energy, and cognitive function after drinking.

03 Recover In-sync

Beyond breaking the cycle, our formula is carefully calibrated to enhance each other's effectiveness— amplifying, synergising, and accelerating your recovery.

01 | Dual-Phase Detox

Curcumin and DHM work in tandem to accelerate acetaldehyde breakdown. DHM boosts alcohol‐metabolizing enzymes, speeding initial toxin conversion, while curcumin supports antioxidant defenses (SOD, GPx).[40]

02 | Gut–Liver Axis Amplification

Beyond liver detoxification, turmeric and probiotics complement each other to achieve enhanced effectiveness. Probiotics enhance the absorption of turmeric in your gut lining, and turmeric increases the bioavailability of probiotics.[41]

03 | Integrated Antioxidant Shield

Citrus sinensis bioflavonoids pair with curcumin and DHM to neutralize reactive oxygen species (ROS)[42]generated during alcohol metabolism. Probiotics support this trio by enhancing protection against further ROS production. The combined effect is a robust, multi-layered defense against oxidative stress[43]—helping your body recover more fully.